Dimethyl sulfoxide (DMSO) is a straightforward and available naturally occurring chemical that quickly enters the physique by means of the pores and skin and has a wide range of exceptional therapeutic properties. When it was found, its proponents realized it represented a brand new therapeutic precept in medication and as soon as adopted, would fully change how medication was practiced.
In flip, they carried out hundreds of research demonstrating DMSO’s overwhelming security and efficacy in a whole bunch of hundreds of individuals, however sadly, the FDA carried out a reprehensible marketing campaign in opposition to DMSO1 that finally made it turn out to be a Forgotten Facet of Medication.
Within the Sixties a miraculous therapy for continual ache, traumatic damage, strokes and spinal wire paralysis was found that unfold throughout America like wildfire—till the FDA buried it.
Right here, 60 Minutes uncovered the FDA utilizing the identical playbook they used all through COVID-19. A🧵 pic.twitter.com/Bh0dcjNk5w
— A Midwestern Physician (@MidwesternDoc) October 14, 2024
During the last month, I’ve begun presenting that proof. For instance:
- I confirmed right here how DMSO transforms the administration of strokes, spinal wire accidents, psychological incapacity and a wide range of circulatory issues (e.g., Raynaud’s, Varicose Veins and Hemorrhoids).
- I confirmed right here how DMSO treats continual ache, arthritis, burns, wounds and traumatic accidents (e.g., sprains and sports activities accidents) right here.
- I confirmed right here how DMSO is among the most secure medical substances in existence.
In flip, colleagues reminiscent of Pierre Kory have begun utilizing DMSO and reporting exceptional outcomes. Likewise, I’ve obtained a whole bunch of extraordinary tales from readers who’ve gotten their lives again due to DMSO (which will be learn right here) and match precisely what the early pioneers of DMSO noticed. At the moment, I’ll give attention to among the different vital makes use of for DMSO.
Notice: Whereas I’ve my very own most popular manufacturers of DMSO, most formulations work. When buying DMSO, if getting the liquid kind, it is very important make certain the DMSO is of excessive purity and saved in a glass container (the gel kind additionally works and is less complicated to use however can also be extra prone to be irritating and never at all times as potent).
When making use of DMSO topically, it is very important ensure you will not be allergic to it (with a small pores and skin take a look at), that your pores and skin is clear (so no chemical toxins are by accident absorbed as effectively) and to solely use the utmost focus one’s pores and skin simply tolerates (which generally is 70% however can differ from 30% to 100%).
DMSO and Protein Problems
DMSO provides a groundbreaking method to treating complicated diseases by stabilizing misfolded proteins,2 a key subject in lots of genetic issues. In contrast to dear medication that try and handle these issues with restricted success, DMSO’s protein-folding help can deal with a broad vary of circumstances, together with cystic fibrosis,3 amyloidosis4,5,6,7 and even difficult neurological ailments.8,9,10 DMSO’s impact right here is remarkably common.
Notice: Bettering the physiologic zeta potential (an method we usually use to deal with circulatory issues) also can stabilize protein folding (whereas worsening it causes aggregation and misfolding). Likewise, DMSO has been proven11 to dissolve quite a few enzymes with out irreversibly inhibiting them, which authors felt advised DMSO might compensate for genetically faulty enzymes.12
Remarkably, DMSO has proven promise in treating prion ailments like Creutzfeldt-Jakob,13 Alzheimer’s,14 and Parkinson’s. Testimonials reveal DMSO’s energy, with stories of improved motion, vitality, and coordination. For instance, one reader utilizing it for Parkinson’s skilled diminished stiffness, sooner motion, and improved motor abilities.15
Whereas I’m very open-minded to unconventional medical concepts and knew DMSO might deal with a wide range of in any other case incurable neurological ailments (e.g., ALS), there was one factor I at all times had a little bit of problem believing.
DMSO allegedly had been proven to treatment Down Syndrome, demonstrated each in three scientific trials16,17,18 and memorable case stories19 that have been offered by a number of corroborating medical witnesses in Congressional testimony, together with quite a few research displaying DMSO improved the cognition and conduct of developmentally delayed kids.20,21,22,23
To elucidate this inconceivable profit, I theorized it was doubtless attributable to DMSO’s protein stabilizing advantages, as Down Syndrome is characterised by “the aberrant accumulation of unfolded/misfolded proteins ensuing from over-burdened protein high quality management methods.”24
What I discover notably noteworthy about that is that the “untreatability” of genetic issues (which generally consequence from a dysfunctional protein) has justified spending unimaginable quantities of cash on each analysis and coverings for them (e.g., the trade remains to be in its early levels however 20.4 billion is already spent annually on gene therapies in america25 — which partially explains why there was such a push to carry the unsafe mRNA platform onto the market and open up a large new drug sector).
In distinction, DMSO is nearly free and has been proven to deal with many of those issues we nonetheless don’t have a superb possibility for.
Collagen Problems
Irregular collagen buildup contributes to many ailments, together with rheumatologic and degenerative ageing circumstances. DMSO, identified for addressing protein buildup, additionally “softens” collagen, benefiting numerous collagen issues. It helps by:
- Regulating MMP-9 exercise to help orderly therapeutic, decreasing fibrotic ailments.26
- Decreasing adhesions from surgical procedure27 and eliminating radiation-induced fibrosis.28
- Treating keloids29 by loosening collagen bundles30 to flatten scars.
- Strengthening incisions31 and scars to forestall extreme scar formation32 post-surgery.
Notice: Many different stories of DMSO benefitting collagen issues (e.g., this symposium, which offered knowledge on 9,521 sufferers with a wide range of circumstances reminiscent of Dupuytren’s contractures33) additionally exist.
DMSO has proven promising results on collagen-related issues like Dupuytren’s and Peyronie’s, each of which contain irregular collagen buildup. Early research, together with one from 1965,34 confirmed that DMSO improved vary of movement in scleroderma and diminished plaque in Dupuytren’s contracture.
Dupuytren’s Contracture
This situation entails thickened collagen within the palm, inflicting finger contractures. Customary remedies like collagen-digesting injections, needle aponeurotomy, or surgical procedure can have problems and excessive recurrence charges.35 Early stories famous that long-term DMSO use led to enhancements, with 3 out of three sufferers responding positively in a single examine,36 and partial or full remissions in others.37
Nevertheless, effectiveness appears greater when DMSO is used early, at greater concentrations, and over a chronic interval.
Peyronie’s Illness
Peyronie’s causes painful scarring and curvature of the penis, and whereas remedies exist, they typically do not absolutely resolve the difficulty. DMSO, particularly when utilized early, has been reported to scale back plaque measurement and ache. Notably, Dr. Stanley Jacob in Portland noticed reduction in about half of his sufferers.38 Analysis from the Cleveland Urologists discovered that 6 of 13 males noticed sufficient enchancment to renew regular intercourse,39 with some experiencing diminished plaques and even full decision.
Notice: Whereas DMSO doesn’t have a 100% treatment fee for Dupuytren’s or Peyronie’s, it typically works and in contrast to the opposite choices is devoid of unintended effects. As a result of DMSO works greatest when used early and will be utilized discreetly at dwelling, it provides a strong and accessible possibility for these coping with these circumstances — particularly Peyronie’s illness.
Rheumatoid Arthritis Contractures
DMSO has additionally confirmed helpful for flexion contractures from rheumatoid arthritis, the place it elevated joint flexibility by 20 to 30 levels with out relapse after a follow-up.40
Fibrodysplasia Ossificans Progressiva (FOP)
FOP, a uncommon genetic dysfunction inflicting muscle tissues and ligaments to progressively flip into bone, is normally thought-about terminal and incurable. But, sufferers in research have improved from DMSO (e.g., one regained some shoulder and hand motion and noticed smaller calcified lumps).41
Scleroderma
“In the course of the eight months I’ve been testing DMS:
- I’ve been capable of stroll and drive a automobile (I had been consigned to a wheelchair by medical doctors on the College of Michigan Medical Middle)
- My horrible swallowing downside attributable to a calcified esophagus has improved, though I nonetheless eat child meals meats
- I nonetheless have 9 fingers left, free so removed from amputation
I am preventing for a change in drug analysis to offer hundreds of different folks a way forward for some promise.”42
Scleroderma is a devastating illness characterised by hardening and thickening of the pores and skin, beginning with blood vessels and doubtlessly spreading to muscle tissues, joints, and inside organs, the place it typically turns into deadly.43 Regardless of years of analysis, choices stay restricted, with poor survival charges and frequent problems like ulcers, impaired mobility, and lack of fingers or toes attributable to poor circulation.44
Early analysis discovered DMSO to be remarkably useful for scleroderma, typically prompting affected person protests in opposition to the FDA’s refusal to approve it.45 Research confirmed DMSO’s effectiveness in therapeutic ulcers, softening hardened pores and skin, bettering circulation, and even decreasing collagen buildup.
In a landmark examine of 42 scleroderma sufferers,46 62% skilled notable enhancements, with a number of even reaching remission. Many sufferers needed to proceed DMSO use to take care of advantages, however the outcomes have been life-changing.
Notice: This examine was initially impressed by the popularity that DMSO could be very efficient at treating ache, and scleroderma is commonly fairly painful.
In a later examine on the Cleveland Clinic, DMSO elevated joint flexibility, restored pores and skin suppleness, and improved grip power.47 Russian researchers additionally noticed fast enhancements in over 90% of scleroderma sufferers, with many experiencing no relapses as much as 5 years later.48
Testimonials from sufferers, together with a passionate plea earlier than Congress, highlighted DMSO’s potential as a secure and impactful therapy — although it is nonetheless uncommon for contemporary rheumatologists to know a lot about it.49 Moreover, quite a few rheumatologists surveyed by Congress discovered it efficient for scleroderma.50
Different Autoimmune Circumstances
Within the first two components of this collection51,52 I offered in depth analysis demonstrating DMSO’s potential to forestall or resolve experimentally induced irritation (or tissue necrosis) and analysis mapping out DMSO’s particular anti-inflammatory properties (e.g., it inhibits quite a few inflammatory cytokines), and a wealth of information displaying it was an efficient therapy for rheumatoid arthritis.
DMSO in flip, is effectively acknowledged for its anti-inflammatory actions, and a few of my colleagues have used it for this goal for years. Likewise, many authors have mentioned its use in a wide range of autoimmune issues (e.g., this writer mentioned how DMSO can typically be fairly useful for idiopathic thrombocytopenic purpura53). Within the part under, I’ll focus on its use in a number of key autoimmune circumstances.
1. Interstitial cystitis (IC)
• Overview — IC, also called painful bladder syndrome, can drastically have an effect on high quality of life, resulting in frequent and pressing urination — generally as much as 50 occasions a day — typically accompanied by pelvic ache, bladder irritation, and even blood within the urine.
• DMSO therapy — Administered as RIMSO-50, DMSO has FDA approval particularly for IC. It really works by assuaging ache54 and decreasing irritation55 within the bladder wall, selling rest of bladder muscle tissues56 and stopping scar tissue formation.57
• Outcomes — Scientific stories present that many sufferers expertise substantial reduction, with response charges various between research however typically demonstrating a major discount in signs reminiscent of ache and urgency.58,59,60,61,62
2. Lupus
• Overview — Lupus is a fancy autoimmune illness that may trigger widespread irritation and injury to varied physique methods. Sufferers typically wrestle with continual signs and discover conventional remedies insufficient.
• DMSO functions — Experiences recommend that DMSO could successfully alleviate signs in lupus sufferers, even these unresponsive to steroids. Notably, some circumstances have proven DMSO resulting in remission of lupus-related interstitial cystitis,63 demonstrating its multifaceted advantages.
• Potential affect — As a possible various or adjunct remedy,64 DMSO provides hope for these in search of higher administration of their lupus signs.
3. Bronchial asthma
• Overview — Bronchial asthma is characterised by irritation and narrowing of the airways, resulting in problem respiration. Conventional remedies typically depend on bronchodilators and corticosteroids.
• DMSO advantages — Analysis signifies that DMSO could cut back the severity of bronchial asthma signs, notably when used along side different therapies. Some research report65 that DMSO can lower the frequency and dosage of bronchial asthma medicines required, with some sufferers even eliminating the necessity for medicines altogether.
• Influence — This might considerably improve the standard of life for bronchial asthma victims, offering them with extra management over their situation.
4. A number of sclerosis (MS)
• Overview — MS is a continual illness affecting the central nervous system, resulting in a variety of neurological signs that may differ significantly between people and sometimes can’t be absolutely managed with standard care.
• DMSO advantages — A Russian examine of 34 MS sufferers discovered DMSO offered important profit to them.66
• DMSO case research — Anecdotal proof reveals that some MS sufferers have skilled exceptional enhancements following DMSO therapy.67
Notice: There was additionally a reported case68 of Stanley Jacob treating a affected person with ALS which resulted in “some prompt, in a single day and barely delayed wonders of remedy,” and this consumer reported69 she noticed it visibly enhance the situation. In our personal expertise IV DMSO is among the solely issues which may deal with ALS (usually it halts the development of the illness).
5. Uveitis
• Overview — Uveitis is an irritation of the center layer of the attention, which may trigger ache, gentle sensitivity, and imaginative and prescient modifications.
• DMSO analysis — Research carried out on canine with uveitis have proven that DMSO successfully reduces each irritation and intraocular stress.70
• Human software potential — This promising analysis means that DMSO may very well be explored as a therapy possibility for people affected by related inflammatory eye circumstances, notably since DMSO treats many different ocular issues.
6. Inflammatory bowel ailments (IBD)
• Overview — Circumstances like gastritis, ulcerative colitis and Crohn’s illness result in continual irritation of the digestive tract, leading to signs like belly ache, diarrhea, and fatigue.
• Efficacy of DMSO — Analysis highlights DMSO’s potential to scale back relapse charges and inflammatory markers when added to plain therapies for ulcerative colitis.71
• Scientific significance — By enhancing the effectiveness of present remedies, DMSO could present a pathway to higher administration of IBD72 and improved affected person outcomes. Lots of my colleagues discover DMSO is exceptionally useful for IBD.
7. Myasthenia gravis (MG)
• Overview — MG is an autoimmune dysfunction that impacts communication between nerves and muscle tissues, resulting in weak spot and fatigue.
• DMSO mechanism — Animal research point out that DMSO can cut back ranges of acetylcholine receptor antibodies,73 which play an important function within the illness’s pathology.
• Future instructions — Whereas human research are missing, this analysis opens the door for potential therapeutic methods involving DMSO in managing MG.
Notice: DMSO has additionally been proven to suppress thyroid autoantibodies74 (a standard reason behind hypothyroidism).
8. Sjogren’s syndrome — Sjogren’s syndrome (autoimmunity of the parotid gland) leads to a lack of saliva and the mouth changing into very dry. Since it’s a very troublesome situation to deal with, this desk inside a bigger examine75 caught my eye:
Conclusion
On the time these discoveries have been made greater than fifty years in the past, they have been revolutionary, many nonetheless are (e.g., standard medication nonetheless can not deal with lots of the circumstances described right here and clinically, DMSO stays one of the crucial anti-inflammatory brokers accessible to us).
Because of this, many physicians and determined sufferers from across the nation fought to make DMSO be legalized, however exterior of its slim indication for interstitial cystitis, the FDA refused to relent76 — even after many congressional representatives and senators spent a long time making an attempt to drive the FDA to.
Relatively, it was solely after the general public turned so disgusted with the FDA conducting police model raids in opposition to pure medication and Congress handed the 1994 DSHEA Act77 which prohibited the FDA from regulating naturally occurring dietary supplements that issues modified (as DMSO happens in nature).
Sadly, by the point this occurred, the injury was completed and only a few remembered the unimaginable potential DMSO needed to remodel all the observe of medication — regardless of the very fact a whole bunch of hundreds of People have been utilizing DMSO within the not too distant previous.
Worse nonetheless, these monopolistic techniques by no means stopped, and so many exceptional therapies which might have helped all of humanity have been erased by the medical trade (e.g., take into account how onerous the FDA fought to bury hydroxychloroquine and ivermectin throughout COVID-19 so the unconscionable mRNA vaccines would face no competitors).
Fortuitously (as a result of fast diffusion of knowledge facilitated by social media), these techniques have provoked such a powerful backlash that a unprecedented, a once-in-a-lifetime alternative has been created, and subsequent week we’ll eventually have an opportunity to repair this dysfunctional paradigm:
FDA’s struggle on public well being is about to finish. This consists of its aggressive suppression of psychedelics, peptides, stem cells, uncooked milk, hyperbaric therapies, chelating compounds, ivermectin, hydroxychloroquine, nutritional vitamins, clear meals, sunshine, train, nutraceuticals and something…
— Robert F. Kennedy Jr (@RobertKennedyJr) October 25, 2024
In flip, I really feel extremely blessed to stay in an period the place The Forgotten Sides of Medication can eventually be rediscovered and to have been given the chance by the pure well being neighborhood to assist make that occur. For many years I by no means imagined what we’re seeing now might ever be doable.
Writer’s word: That is an abridged model of an extended article that goes into larger element on the factors talked about right here, examines the weird mechanisms that enable DMSO to deal with so many alternative inflammatory circumstances, and gives steering for private DMSO use (e.g., dosing, therapeutic precautions and the place to acquire it).
That article and its extra references will be learn right here (together with a companion article discussing DMSO’s life-changing utility for a wide range of musculoskeletal accidents and continual ache circumstances).
A Notice from Dr. Mercola In regards to the Writer
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I respect AMD’s distinctive perception on a variety of matters and am grateful to share it. I additionally respect AMD’s want to stay nameless since AMD remains to be on the entrance strains treating sufferers. To seek out extra of AMD’s work, you should definitely try The Forgotten Facet of Medication on Substack.